How do standard folic acid (FA) and active 5-methyltetrahydrofolate (5-MTHF) compare when dosed equimolarly in pregnancy? Synthetic FA must be reduced and remethylated—MTHFR is a key step—to yield circulating 5-MTHF. MTHFR variants are relatively common in Asian populations; direct 5-MTHF supplementation can bypass that bottleneck in theory. Head-to-head, adequately powered RCTs in pregnant women have

Nutrition epidemiology often asks what people eat. A large Chinese cohort asks a complementary question: does the accumulation of how people eat predict mortality? Researchers at The Third Xiangya Hospital reported in American Journal of Preventive Cardiology (2025) on 57,737 adults from domestic health examinations. They built a weighted composite of 23 dietary habits and

New Review: PQQ’s Neuroprotective Effects — From Mitochondrial Repair to Treating Cerebral Folate Deficiency With the acceleration of global population aging, the incidence of neurodegenerative diseases and neurodevelopmental disorders continues to rise. Central nervous system (CNS) disorders such as Alzheimer’s disease, Parkinson’s disease, and cerebral folate deficiency place a heavy burden on patients, families, and

International expert consensus: Here are the answers to 22 clinical questions about oral nutritional supplements Malnutrition is a common challenge faced by the global healthcare industry, especially among chronic disease patients and the elderly population, which is closely related to prolonged hospitalization, increased complications, functional decline, and increased mortality. **Oral nutritional supplements (ONS) are an

New study: Nutritional management and supplementation strategies for patients with congenital heart disease *For patients with congenital heart disease, nutritional management is not only the foundation for maintaining health, but also an important means of delaying disease progression and improving prognosis. However, with the continuous growth and aging of the patient population, issues such as

New research review: Vitamin supplements fail to improve cardiovascular outcomes in the general population Vitamin supplements have long been promoted as an effective means of maintaining cardiovascular health, especially in the context of increasing global health awareness, and their usage continues to rise. However, a comprehensive review study recently published in Clinical Nutrition ESPEN has

New research: Dietary supplements may improve emotional symptoms in children with autism Autism spectrum disorder (ASD) is a neurodevelopmental disorder with a high incidence rate worldwide. In addition to the core symptoms, children are often accompanied by emotional problems such as irritability and anxiety, which seriously affect the quality of life. Recently, a team from

New research reveals that the key to plant sterols lowering cholesterol lies in intestinal esterification Plant sterols have long been used for cardiovascular health management due to their natural cholesterol lowering effects. However, its extremely low bioavailability (less than 5%) has always been a bottleneck limiting its application effectiveness. Recently, a research team from Zhejiang