{"id":22982,"date":"2026-11-10T17:38:49","date_gmt":"2026-11-10T09:38:49","guid":{"rendered":"https:\/\/health.nugene.com.cn\/?page_id=22982"},"modified":"2026-11-10T17:42:23","modified_gmt":"2026-11-10T09:42:23","slug":"tudca","status":"publish","type":"page","link":"https:\/\/health.nugene.com.cn\/index.php\/tudca\/","title":{"rendered":"TUDCA"},"content":{"rendered":"\n<style>\n\n#tudca-page{\n  --navy:#0B2432; --navy2:#103246; --navy3:#17435A; --navy4:#225A73;\n  --gold:#E5B24C; --gold2:#F2D28C; --gold-dim:rgba(229,178,76,.16);\n  --ink:#142732; --body:#3E5663; --muted:#718894;\n  --line:#DDE7EC; --line2:#EAF1F4; --bg:#F5F8FA; --card:#FFFFFF;\n  --ok:#1E8F6B; --warn:#B5761C;\n  --shadow:0 10px 34px rgba(11,36,50,.08);\n  --shadow2:0 18px 48px rgba(11,36,50,.14);\n  --radius:14px; --max:1200px;\n  --sans:\"PingFang SC\",\"Microsoft YaHei\",\"Hiragino Sans GB\",\"Noto Sans SC\",\"Source Han Sans SC\",-apple-system,BlinkMacSystemFont,\"Segoe UI\",Arial,sans-serif;\n}\n#tudca-page,#tudca-page *{box-sizing:border-box}\nhtml:has(#tudca-page){scroll-behavior:smooth;scroll-padding-top:24px}\n#tudca-page{margin:0;background:var(--bg);color:var(--body);font-family:var(--sans);font-size:15px;line-height:1.85;-webkit-font-smoothing:antialiased}\n#tudca-page img{max-width:100%;display:block}\n#tudca-page a{color:inherit;text-decoration:none}\n#tudca-page h1,#tudca-page h2,#tudca-page h3,#tudca-page h4,#tudca-page p,#tudca-page ul,#tudca-page ol,#tudca-page figure{margin:0}\n#tudca-page ul{padding:0;list-style:none}\n#tudca-page button{font-family:inherit;cursor:pointer}\n#tudca-page table{border-collapse:collapse;width:100%}\n#tudca-page :focus-visible{outline:2px solid var(--gold);outline-offset:3px}\n#tudca-page .wrap{width:min(var(--max),calc(100% - 48px));margin:0 auto}\n#tudca-page .mono{font-family:\"SFMono-Regular\",Consolas,\"Liberation Mono\",Menlo,monospace;font-variant-numeric:tabular-nums}\n\n\/* ---------- top utility bar ---------- *\/\n#tudca-page .utility{background:#071B27;color:#A9C0CC;font-size:12px;letter-spacing:.02em}\n#tudca-page .utility .wrap{display:flex;align-items:center;justify-content:space-between;gap:20px;min-height:36px}\n#tudca-page .utility b{color:var(--gold2);font-weight:600}\n#tudca-page .utility a:hover{color:#fff}\n#tudca-page .utility .u-left,#tudca-page .utility .u-right{display:flex;align-items:center;gap:20px;flex-wrap:wrap}\n#tudca-page .utility .sep{width:1px;height:12px;background:rgba(255,255,255,.18)}\n\n\/* ---------- header ---------- *\/\n#tudca-page .site-header{position:sticky;top:0;z-index:60;background:rgba(255,255,255,.96);backdrop-filter:saturate(160%) blur(12px);border-bottom:1px solid var(--line);box-shadow:0 2px 14px rgba(11,36,50,.04)}\n#tudca-page .header-inner{display:flex;align-items:center;gap:28px;min-height:76px}\n#tudca-page .brand{display:flex;align-items:center;gap:11px;flex-shrink:0}\n#tudca-page .brand-mark{width:38px;height:38px;border:2px solid var(--navy);border-radius:10px;display:grid;place-items:center;position:relative}\n#tudca-page .brand-mark:before{content:\"\";position:absolute;width:16px;height:16px;border:2px solid var(--gold);border-radius:50%}\n#tudca-page .brand-mark:after{content:\"\";position:absolute;width:5px;height:5px;background:var(--navy);border-radius:50%}\n#tudca-page .brand-txt strong{display:block;color:var(--navy);font-size:16px;line-height:1.25;letter-spacing:.06em;font-weight:800}\n#tudca-page .brand-txt span{display:block;font-size:9px;letter-spacing:.13em;color:var(--muted);text-transform:uppercase;white-space:nowrap}\n#tudca-page .main-nav{margin-left:auto}\n#tudca-page .main-nav>ul{display:flex;align-items:center;gap:4px}\n#tudca-page .main-nav li{position:relative}\n#tudca-page .main-nav a.nav-link{display:block;padding:10px 14px;font-size:14px;font-weight:600;color:var(--ink);border-radius:8px;white-space:nowrap;transition:.2s}\n#tudca-page .main-nav a.nav-link:hover,#tudca-page .main-nav li.active>a.nav-link{background:var(--gold-dim);color:var(--navy)}\n#tudca-page .main-nav a.nav-link .caret{display:inline-block;margin-left:5px;width:6px;height:6px;border-right:1.5px solid currentColor;border-bottom:1.5px solid currentColor;transform:rotate(45deg) translateY(-2px)}\n#tudca-page .dropdown{position:absolute;top:calc(100% + 8px);left:0;min-width:224px;background:#fff;border:1px solid var(--line);border-radius:12px;box-shadow:var(--shadow2);padding:8px;opacity:0;visibility:hidden;transform:translateY(6px);transition:.2s}\n#tudca-page .main-nav li:hover>.dropdown,#tudca-page .main-nav li:focus-within>.dropdown{opacity:1;visibility:visible;transform:none}\n#tudca-page .dropdown a{display:flex;justify-content:space-between;gap:12px;padding:9px 12px;border-radius:8px;font-size:13px;color:var(--body)}\n#tudca-page .dropdown a:hover{background:var(--bg);color:var(--navy)}\n#tudca-page .dropdown a em{font-style:normal;color:var(--muted);font-size:11px}\n#tudca-page .header-actions{display:flex;align-items:center;gap:12px;flex-shrink:0}\n#tudca-page .lang{font-size:12px;color:var(--muted);border:1px solid var(--line);padding:5px 9px;border-radius:6px;white-space:nowrap}\n#tudca-page .lang:hover{border-color:var(--gold);color:var(--navy)}\n#tudca-page .btn{display:inline-flex;align-items:center;justify-content:center;gap:8px;border-radius:8px;padding:11px 20px;font-size:14px;font-weight:700;border:1px solid transparent;transition:.22s;white-space:nowrap}\n#tudca-page .btn-gold{background:var(--gold);color:#12222C}\n#tudca-page .btn-gold:hover{background:#F2C566;transform:translateY(-2px);box-shadow:0 10px 22px rgba(229,178,76,.3)}\n#tudca-page .btn-outline{border-color:rgba(255,255,255,.42);color:#fff;background:transparent}\n#tudca-page .btn-outline:hover{border-color:var(--gold);color:var(--gold2)}\n#tudca-page .btn-navy{background:var(--navy);color:#fff}\n#tudca-page .btn-navy:hover{background:var(--navy3);transform:translateY(-2px)}\n#tudca-page .btn-ghost{border-color:var(--line);background:#fff;color:var(--navy)}\n#tudca-page .btn-ghost:hover{border-color:var(--navy3);color:var(--navy3)}\n#tudca-page .menu-toggle{display:none;width:42px;height:38px;border:1px solid var(--line);background:#fff;border-radius:8px;align-items:center;justify-content:center;flex-direction:column;gap:5px}\n#tudca-page .menu-toggle span{display:block;width:19px;height:2px;background:var(--navy)}\n\n\/* ---------- subnav ---------- *\/\n#tudca-page .subnav{background:var(--navy);border-top:1px solid rgba(255,255,255,.08)}\n#tudca-page .subnav .wrap{display:flex;align-items:center;gap:6px;overflow-x:auto;scrollbar-width:none}\n#tudca-page .subnav .wrap::-webkit-scrollbar{display:none}\n#tudca-page .subnav a{padding:13px 15px;font-size:13px;color:#B9CDD7;white-space:nowrap;border-bottom:2px solid transparent;transition:.2s}\n#tudca-page .subnav a:hover,#tudca-page .subnav a.on{color:#fff;border-bottom-color:var(--gold)}\n\n\/* ---------- breadcrumb ---------- *\/\n#tudca-page .crumb{background:#fff;border-bottom:1px solid var(--line2);font-size:12.5px;color:var(--muted)}\n#tudca-page .crumb .wrap{display:flex;align-items:center;gap:9px;min-height:44px;flex-wrap:wrap}\n#tudca-page .crumb a:hover{color:var(--navy3)}\n#tudca-page .crumb span.cur{color:var(--ink);font-weight:600}\n\n\/* ---------- hero ---------- *\/\n#tudca-page .hero{position:relative;overflow:hidden;background:linear-gradient(124deg,#071C28 0%,#0B2C3E 52%,#124357 100%);color:#fff}\n#tudca-page .hero:before{content:\"\";position:absolute;inset:0;background:\n  radial-gradient(720px 460px at 78% 18%,rgba(229,178,76,.16),transparent 70%),\n  radial-gradient(560px 420px at 8% 92%,rgba(47,139,170,.22),transparent 72%),\n  linear-gradient(rgba(255,255,255,.028) 1px,transparent 1px),linear-gradient(90deg,rgba(255,255,255,.028) 1px,transparent 1px);\n  background-size:auto,auto,42px 42px,42px 42px}\n#tudca-page .hero:after{content:\"\";position:absolute;right:-120px;bottom:-190px;width:520px;height:520px;border:1px solid rgba(229,178,76,.18);border-radius:50%;box-shadow:0 0 0 60px rgba(229,178,76,.045),0 0 0 130px rgba(229,178,76,.03)}\n#tudca-page .hero-inner{position:relative;z-index:2;display:grid;grid-template-columns:1.12fr .88fr;gap:64px;align-items:center;padding:78px 0 84px}\n#tudca-page .eyebrow{display:inline-flex;align-items:center;gap:10px;font-size:12px;letter-spacing:.22em;text-transform:uppercase;color:var(--gold2);font-weight:700}\n#tudca-page .eyebrow:before{content:\"\";width:28px;height:2px;background:var(--gold)}\n#tudca-page .hero h1{font-size:clamp(36px,4.4vw,58px);line-height:1.18;letter-spacing:.01em;margin:20px 0 10px;font-weight:800;color:#fff}\n#tudca-page .hero h1 small{display:block;font-size:clamp(17px,1.7vw,23px);letter-spacing:.14em;font-weight:500;color:var(--gold2);margin-top:10px;text-transform:uppercase}\n#tudca-page .hero .lead{font-size:16px;line-height:1.95;color:#C7D9E2;max-width:560px;margin:20px 0 26px}\n#tudca-page .hero .lead strong{color:#fff}\n#tudca-page .chips{display:flex;gap:10px;flex-wrap:wrap;margin-bottom:30px}\n#tudca-page .chip{border:1px solid rgba(255,255,255,.24);background:rgba(255,255,255,.06);border-radius:999px;padding:6px 14px;font-size:12.5px;color:#DCE9EF}\n#tudca-page .chip b{color:var(--gold2);font-weight:700}\n#tudca-page .hero-cta{display:flex;gap:12px;flex-wrap:wrap}\n#tudca-page .hero-kpi{display:grid;grid-template-columns:repeat(3,1fr);gap:0;margin-top:44px;border-top:1px solid rgba(255,255,255,.16);padding-top:22px;max-width:560px}\n#tudca-page .hero-kpi div+div{border-left:1px solid rgba(255,255,255,.16);padding-left:18px}\n#tudca-page .hero-kpi div{padding-right:14px}\n#tudca-page .hero-kpi b{display:block;font-size:25px;line-height:1.3;color:var(--gold2);font-weight:800}\n#tudca-page .hero-kpi span{font-size:11.5px;color:#A9C1CD;letter-spacing:.04em}\n\n\/* identity card *\/\n#tudca-page .idcard{background:rgba(255,255,255,.075);border:1px solid rgba(255,255,255,.18);border-radius:20px;padding:26px 28px;backdrop-filter:blur(10px);box-shadow:0 24px 60px rgba(0,0,0,.22)}\n#tudca-page .idcard h3{font-size:13px;letter-spacing:.18em;color:var(--gold2);text-transform:uppercase;margin-bottom:18px;font-weight:700}\n#tudca-page .struct{height:172px;border-radius:12px;background:rgba(7,27,39,.35);border:1px solid rgba(255,255,255,.09);display:grid;place-items:center;margin-bottom:20px}\n#tudca-page .struct svg{width:100%;height:100%;max-width:320px}\n#tudca-page .idgrid{display:grid;grid-template-columns:1fr 1fr;gap:0}\n#tudca-page .idgrid div{padding:11px 0;border-bottom:1px solid rgba(255,255,255,.1)}\n#tudca-page .idgrid div:nth-child(odd){padding-right:14px}\n#tudca-page .idgrid div:nth-child(even){padding-left:14px;border-left:1px solid rgba(255,255,255,.1)}\n#tudca-page .idgrid span{display:block;font-size:11px;color:#9DB8C5;letter-spacing:.06em}\n#tudca-page .idgrid b{display:block;font-size:14px;color:#fff;font-weight:600;margin-top:2px;word-break:break-word}\n#tudca-page .idnote{font-size:11px;color:#91ACBA;margin-top:14px;line-height:1.7}\n\n\/* ---------- section common ---------- *\/\n#tudca-page section{padding:76px 0}\n#tudca-page section.tint{background:#fff}\n#tudca-page .sec-head{margin-bottom:38px;max-width:820px}\n#tudca-page .sec-head .tag{display:inline-flex;align-items:center;gap:9px;color:var(--navy4);font-size:11.5px;font-weight:800;letter-spacing:.2em;text-transform:uppercase}\n#tudca-page .sec-head .tag:before{content:\"\";width:22px;height:2px;background:var(--gold)}\n#tudca-page .sec-head h2{font-size:clamp(26px,3vw,36px);line-height:1.3;color:var(--navy);font-weight:800;margin:14px 0 12px;letter-spacing:.01em}\n#tudca-page .sec-head p{font-size:15px;color:var(--body);line-height:1.9}\n#tudca-page .sec-head .en{font-size:12px;letter-spacing:.16em;color:var(--muted);text-transform:uppercase;margin-bottom:6px}\n\n\/* two-col intro *\/\n#tudca-page .split{display:grid;grid-template-columns:1.05fr .95fr;gap:46px;align-items:start}\n#tudca-page .prose p{font-size:15px;line-height:2.02;margin-bottom:16px}\n#tudca-page .prose strong{color:var(--navy);font-weight:700}\n#tudca-page .prose .hl{border-left:3px solid var(--gold);background:#fff;padding:15px 20px;border-radius:0 10px 10px 0;margin:22px 0;box-shadow:var(--shadow);font-size:14.5px}\n#tudca-page .fact-list{display:grid;gap:12px;margin-top:22px}\n#tudca-page .fact{display:flex;gap:14px;background:#fff;border:1px solid var(--line);border-radius:12px;padding:15px 18px}\n#tudca-page .fact .n{flex:0 0 32px;height:32px;border-radius:8px;background:var(--gold-dim);color:#9A6E14;display:grid;place-items:center;font-weight:800;font-size:13px}\n#tudca-page .fact b{display:block;color:var(--navy);font-size:14.5px;margin-bottom:2px}\n#tudca-page .fact span{font-size:13px;color:var(--body);line-height:1.7}\n#tudca-page .mini-table{background:#fff;border:1px solid var(--line);border-radius:var(--radius);overflow:hidden;box-shadow:var(--shadow)}\n#tudca-page .mini-table h3{font-size:14px;color:var(--navy);padding:16px 20px;border-bottom:1px solid var(--line2);background:#FBFDFF;font-weight:800}\n#tudca-page .mini-table table th,#tudca-page .mini-table table td{padding:10px 18px;font-size:13.5px;border-bottom:1px solid var(--line2);text-align:left}\n#tudca-page .mini-table table th{color:var(--muted);font-weight:500;width:46%}\n#tudca-page .mini-table table td{color:var(--ink);font-weight:600}\n#tudca-page .mini-table table tr:last-child th,#tudca-page .mini-table table tr:last-child td{border-bottom:0}\n#tudca-page .mini-table .foot{font-size:11.5px;color:var(--muted);padding:12px 20px;border-top:1px solid var(--line2);background:#FBFDFF;line-height:1.7}\n\n\/* stat band *\/\n#tudca-page .band{background:var(--navy);color:#fff;padding:0}\n#tudca-page .band .wrap{display:grid;grid-template-columns:repeat(4,1fr);padding:36px 0}\n#tudca-page .band div{padding:6px 22px;border-left:1px solid rgba(255,255,255,.15)}\n#tudca-page .band div:first-child{border-left:0;padding-left:0}\n#tudca-page .band b{display:block;font-size:30px;line-height:1.25;color:var(--gold2);font-weight:800}\n#tudca-page .band span{font-size:12.5px;color:#B7CDD8}\n\n\/* spec tables *\/\n#tudca-page .table-shell{background:#fff;border:1px solid var(--line);border-radius:var(--radius);overflow:hidden;box-shadow:var(--shadow)}\n#tudca-page .table-top{display:flex;justify-content:space-between;align-items:center;gap:16px;flex-wrap:wrap;padding:16px 22px;background:#FBFDFF;border-bottom:1px solid var(--line2)}\n#tudca-page .table-top h3{font-size:15px;color:var(--navy);font-weight:800}\n#tudca-page .table-top p{font-size:12px;color:var(--muted)}\n#tudca-page .table-scroll{overflow-x:auto}\n#tudca-page table.data{font-size:13.5px;min-width:760px}\n#tudca-page table.data thead th{background:var(--navy);color:#fff;font-weight:600;text-align:left;padding:13px 16px;letter-spacing:.03em;white-space:nowrap}\n#tudca-page table.data tbody td{padding:11px 16px;border-bottom:1px solid var(--line2);vertical-align:middle;color:var(--body)}\n#tudca-page table.data tbody tr:last-child td{border-bottom:0}\n#tudca-page table.data tbody tr:hover{background:#FAFCFD}\n#tudca-page table.data td:first-child{color:var(--ink);font-weight:600}\n#tudca-page table.data tr.group td{background:#EEF4F7;color:var(--navy);font-weight:800;letter-spacing:.06em;font-size:12.5px;padding:9px 16px}\n#tudca-page table.data td .val{color:var(--ok);font-weight:700}\n#tudca-page table.data td .em{color:var(--muted);font-size:12px}\n#tudca-page table.data td:last-child{white-space:nowrap;font-size:11.5px}\n#tudca-page .table-note{font-size:11.5px;color:var(--muted);padding:13px 22px;background:#FBFDFF;border-top:1px solid var(--line2);line-height:1.8}\n#tudca-page .table-note b{color:var(--navy)}\n#tudca-page .spec-grid{display:grid;grid-template-columns:1fr;gap:26px}\n@media(max-width:960px){#tudca-page .spec-grid{grid-template-columns:1fr}}\n\n\/* batch cards *\/\n#tudca-page .batch-grid{display:grid;grid-template-columns:repeat(4,1fr);gap:16px}\n#tudca-page .batch{background:#fff;border:1px solid var(--line);border-radius:var(--radius);padding:20px;box-shadow:var(--shadow);position:relative;overflow:hidden}\n#tudca-page .batch:before{content:\"\";position:absolute;left:0;top:0;width:100%;height:3px;background:var(--gold)}\n#tudca-page .batch.peer:before{background:#B8C9D2}\n#tudca-page .batch .batch-no{font-size:12px;color:var(--muted);letter-spacing:.04em}\n#tudca-page .batch h4{font-size:16px;color:var(--navy);margin:4px 0 14px;font-weight:800}\n#tudca-page .batch dl{display:grid;grid-template-columns:1fr auto;gap:6px 10px;margin:0;font-size:12.5px}\n#tudca-page .batch dt{color:var(--muted)}\n#tudca-page .batch dd{margin:0;color:var(--ink);font-weight:600;text-align:right}\n#tudca-page .batch .assay{font-size:22px;color:var(--navy);font-weight:800;margin:14px 0 0;padding-top:12px;border-top:1px dashed var(--line)}\n#tudca-page .batch .assay small{font-size:11px;color:var(--muted);font-weight:500;margin-left:6px}\n#tudca-page .chart{background:#fff;border:1px solid var(--line);border-radius:var(--radius);padding:24px 26px;margin-top:22px;box-shadow:var(--shadow)}\n#tudca-page .chart h3{font-size:15px;color:var(--navy);font-weight:800;margin-bottom:4px}\n#tudca-page .chart .sub{font-size:12px;color:var(--muted);margin-bottom:22px}\n#tudca-page .bar-row{display:grid;grid-template-columns:190px 1fr 70px;gap:14px;align-items:center;margin-bottom:13px;font-size:12.5px}\n#tudca-page .bar-row .lbl{color:var(--body)}\n#tudca-page .bar-track{height:15px;background:#EDF3F6;border-radius:8px;overflow:hidden;position:relative}\n#tudca-page .bar-track .min{position:absolute;left:50%;top:-4px;bottom:-4px;width:2px;background:#B5761C;z-index:2}\n#tudca-page .bar-fill{height:100%;border-radius:8px;background:linear-gradient(90deg,#1C6C88,var(--gold));transform-origin:left;animation:grow 1s ease-out both}\n@keyframes grow{from{transform:scaleX(0)}to{transform:scaleX(1)}}\n#tudca-page .bar-row .num{font-weight:800;color:var(--navy);text-align:right}\n#tudca-page .chart .legend{font-size:11.5px;color:var(--muted);margin-top:12px}\n\n\/* application cards *\/\n#tudca-page .app-grid{display:grid;grid-template-columns:repeat(3,1fr);gap:20px}\n#tudca-page .app{background:#fff;border:1px solid var(--line);border-radius:var(--radius);padding:26px;box-shadow:var(--shadow);transition:.25s;display:flex;flex-direction:column}\n#tudca-page .app:hover{transform:translateY(-5px);box-shadow:var(--shadow2);border-color:#C9DBE4}\n#tudca-page .app .ico{width:46px;height:46px;border-radius:12px;background:var(--gold-dim);display:grid;place-items:center;margin-bottom:18px}\n#tudca-page .app .ico svg{width:24px;height:24px}\n#tudca-page .app .kicker{font-size:11px;letter-spacing:.16em;color:var(--muted);text-transform:uppercase;font-weight:700}\n#tudca-page .app h3{font-size:19px;color:var(--navy);font-weight:800;margin:8px 0 12px}\n#tudca-page .app p{font-size:13.5px;line-height:1.9;flex:1}\n#tudca-page .app ul{margin:16px 0 0;border-top:1px solid var(--line2);padding-top:14px;display:grid;gap:7px}\n#tudca-page .app li{font-size:12.5px;color:var(--body);padding-left:16px;position:relative}\n#tudca-page .app li:before{content:\"\";position:absolute;left:0;top:9px;width:6px;height:6px;border-radius:50%;background:var(--gold)}\n#tudca-page .app .disclaim{font-size:11px;color:var(--muted);margin-top:16px;line-height:1.7;padding-top:12px;border-top:1px dashed var(--line)}\n\n\/* timeline *\/\n#tudca-page 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aria-label=\"Open or close main navigation\">\n<!-- ============ \u9876\u90e8\u4fe1\u606f\u6761\uff08\u5f15\u7528\u5b98\u7f51\uff09 ============ -->\n\n\n<!-- ============ \u7ad9\u70b9\u5bfc\u822a\uff08\u5f15\u7528\u5b98\u7f51\u680f\u76ee\u7ed3\u6784\uff09 ============ -->\n<!-- ==== \u3010\u53ef\u5220\u9664\u00b7\u82e5\u4e3b\u9898\u5df2\u6709\u5168\u7ad9\u5bfc\u822a\u3011\u7ad9\u70b9\u5bfc\u822a \u5f00\u59cb ==== -->\n\n\n<!-- ============ \u9875\u5185\u951a\u70b9\u5bfc\u822a ============ -->\n<!-- ==== \u3010\u53ef\u5220\u9664\u00b7\u82e5\u4e3b\u9898\u5df2\u6709\u5168\u7ad9\u5bfc\u822a\u3011\u9875\u5185\u951a\u70b9\u6761 \u5f00\u59cb ==== -->\n<nav class=\"subnav\" aria-label=\"On-page navigation\">\n  <div class=\"wrap\" id=\"subNav\">\n    <a href=\"#overview\" class=\"on\">Overview<\/a>\n    <a href=\"#spec\">Specifications<\/a>\n    <a href=\"#coa\">Batch COA Data<\/a>\n    <a href=\"#application\">Applications<\/a>\n    <a href=\"#regulatory\">Regulatory &#038; R&#038;D<\/a>\n    <a href=\"#market\">Market &#038; Process<\/a>\n    <a href=\"#delivery\">Packaging &#038; Delivery<\/a>\n    <a href=\"#faq\">FAQ<\/a>\n  <\/div>\n<\/nav>\n\n<div class=\"crumb\">\n  <div class=\"wrap\">\n    <a href=\"https:\/\/health.nugene.com.cn\/\">Home<\/a> \/ <a href=\"https:\/\/shandong.nugene.com.cn\/#products\">Products<\/a> \/ <a href=\"https:\/\/shandong.nugene.com.cn\/#products\">Nutraceutical &amp; Pharma Ingredients<\/a> \/ <span class=\"cur\">Tauroursodeoxycholic Acid (TUDCA)<\/span>\n  <\/div>\n<\/div>\n\n<!-- ============ HERO ============ -->\n<section class=\"hero\" style=\"padding:0\">\n  <div class=\"wrap hero-inner\">\n    <div>\n      <span class=\"eyebrow\">Nutraceutical &amp; Pharmaceutical Ingredient<\/span>\n      <h1>Tauroursodeoxycholic Acid<small>TUDCA \u00b7 CAS 14605-22-2 \u00b7 High-Purity Bile Acid Ingredient<\/small><\/h1>\n      <p class=\"lead\">A <strong>hydrophilic bile acid<\/strong> formed by conjugating ursodeoxycholic acid (UDCA) with taurine. White to off-white crystalline powder; assay  <strong>98.0~102.0%<\/strong> on the anhydrous basis, with measured batches at 99.6-99.8%. A high-purity ingredient for dietary supplements, pharmaceutical formulations and research use.<\/p>\n      <div class=\"chips\">\n        <span class=\"chip\">CAS <b class=\"mono\">14605-22-2<\/b><\/span>\n        <span class=\"chip\">Formula <b class=\"mono\">C<sub>26<\/sub>H<sub>45<\/sub>NO<sub>6<\/sub>S<\/b><\/span>\n        <span class=\"chip\">Standard <b>In-house Standard<\/b><\/span>\n        <span class=\"chip\">Packaging <b>25 kg \/ drum<\/b><\/span>\n      <\/div>\n      <div class=\"hero-cta\">\n        <a class=\"btn btn-gold\" href=\"#contact\">Request Sample &amp; COA \u2192<\/a>\n        <a class=\"btn btn-outline\" href=\"#spec\">View Specifications<\/a>\n      <\/div>\n      <div class=\"hero-kpi\">\n        <div><b class=\"mono\">\u226598%<\/b><span>Assay spec. minimum (HPLC)<\/span><\/div>\n        <div><b class=\"mono\">99.8%<\/b><span>Highest measured batch assay<\/span><\/div>\n        <div><b class=\"mono\">\u226410 ppm<\/b><span>Heavy metals limit<\/span><\/div>\n      <\/div>\n    <\/div>\n\n    <aside class=\"idcard\" aria-label=\"Product identity information\">\n      <h3>Product Identity<\/h3>\n      <div class=\"struct\" aria-label=\"Illustrative tetracyclic fused steroid skeleton\">\n        <svg viewBox=\"0 0 340 170\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" role=\"img\" aria-label=\"Illustrative bile acid tetracyclic backbone with taurine side chain\">\n          <g stroke=\"#E5B24C\" stroke-width=\"1.6\" stroke-linejoin=\"round\" stroke-linecap=\"round\" opacity=\".95\">\n            <path d=\"M38 62 L68 44 L98 62 L98 100 L68 118 L38 100 Z\"\/>\n            <path d=\"M98 62 L128 44 L158 62 L158 100 L128 118 L98 100 Z\"\/>\n            <path d=\"M128 44 L158 26 L188 44 L188 82 L158 100\"\/>\n            <path d=\"M188 44 L218 62 L218 100 L188 118 L158 100\"\/>\n            <path d=\"M188 118 L218 100\"\/>\n          <\/g>\n          <g stroke=\"#8FC4D9\" stroke-width=\"1.5\" stroke-linecap=\"round\" opacity=\".95\">\n            <path d=\"M218 100 L246 100 L262 118 L292 118\"\/>\n            <path d=\"M262 118 L262 142\"\/>\n            <path d=\"M38 100 L22 126\"\/>\n            <path d=\"M188 44 L188 18\"\/>\n            <path d=\"M158 26 L158 8\"\/>\n          <\/g>\n          <g fill=\"#EAF4F8\" font-family=\"Arial, sans-serif\" font-size=\"11\">\n            <text x=\"12\" y=\"140\" fill=\"#EAF4F8\">HO<\/text>\n            <text x=\"182\" y=\"14\" fill=\"#EAF4F8\">CH\u2083<\/text>\n            <text x=\"151\" y=\"8\" fill=\"#EAF4F8\">CH\u2083<\/text>\n            <text x=\"252\" y=\"156\" fill=\"#EAF4F8\">OH<\/text>\n            <text x=\"240\" y=\"112\" fill=\"#F2D28C\" font-size=\"9\">NH\u2013CH\u2082CH\u2082\u2013SO\u2083H<\/text>\n          <\/g>\n          <circle cx=\"218\" cy=\"100\" r=\"3\" fill=\"#E5B24C\"\/><circle cx=\"262\" cy=\"118\" r=\"3\" fill=\"#E5B24C\"\/>\n        <\/svg>\n      <\/div>\n      <div class=\"idgrid\">\n        <div><span>CAS No.<\/span><b class=\"mono\">14605-22-2<\/b><\/div>\n        <div><span>ATC Code<\/span><b class=\"mono\">A05AA02<\/b><\/div>\n        <div><span>Mol. weight (anhydrous)<\/span><b class=\"mono\">499.71<\/b><\/div>\n        <div><span>Mol. weight (dihydrate)<\/span><b class=\"mono\">535.74<\/b><\/div>\n        <div><span>Target \/ Mechanism<\/span><b>GPBAR1 agonist<\/b><\/div>\n        <div><span>Originator<\/span><b>Bruschettini S.r.l. (Italy)<\/b><\/div>\n      <\/div>\n      <p class=\"idnote\">The skeletal diagram indicates the tetracyclic bile acid backbone and is not an exact structural formula. Physicochemical data are drawn from a public drug analysis report (AI developability predictions) and the package insert; the dihydrate molecular weight refers to the drug-product form.<\/p>\n    <\/aside>\n  <\/div>\n<\/section>\n\n<!-- ============ \u6570\u636e\u5e26 ============ -->\n<div class=\"band\">\n  <div class=\"wrap\">\n    <div><b class=\"mono\">6.0~7.5%<\/b><span>Water (crystal water) range<\/span><\/div>\n    <div><b class=\"mono\">\u22640.5%<\/b><span>Total impurities limit<\/span><\/div>\n    <div><b class=\"mono\">200 mesh<\/b><span>Particle size: 85% through <\/span><\/div>\n    <div><b class=\"mono\">24 months<\/b><span>Retest \/ Shelf life<\/span><\/div>\n  <\/div>\n<\/div>\n\n<!-- ============ \u4ea7\u54c1\u6982\u8ff0 ============ -->\n<section id=\"overview\">\n  <div class=\"wrap\">\n    <div class=\"sec-head\">\n      <span class=\"en\">01 \/ Product Overview<\/span>\n      <span class=\"tag\">Overview<\/span>\n      <h2>An increasingly well-studied conjugated bile acid<\/h2>\n      <p>TUDCA is the taurine conjugate of ursodeoxycholic acid (UDCA). It occurs naturally in the human body, though only in trace amounts. Acting as a &#8216;chemical chaperone&#8217;, it alleviates endoplasmic reticulum stress, stabilises mitochondria and suppresses apoptotic signalling, which keeps it in focus across hepatobiliary health, metabolism and neuroprotection research.<\/p>\n    <\/div>\n    <div class=\"split\">\n      <div class=\"prose\">\n        <p><strong>From molecule to function.<\/strong> TUDCA is formed by condensing the carboxyl group of UDCA with the amino group of taurine, and is more hydrophilic than UDCA. The package insert describes its pharmacology as increasing bile acid secretion, altering bile acid composition, inhibiting hepatic cholesterol synthesis and lowering the cholesterol saturation index of bile, thereby supporting the gradual dissolution of cholesterol gallstones.<\/p>\n        <p><strong>From drug to dietary supplement.<\/strong> As a drug, tauroursodeoxycholic acid capsules (TAUROLITE\u00ae, 250 mg) are approved in China for dissolving cholesterol gallstones. As a supplement ingredient, overseas finished products are mainly 250 mg \/ 500 mg capsules, with typical daily intakes of 500-1500 mg, mostly in liver and digestive health formulas.<\/p>\n        <div class=\"hl\">Note: apart from the approved hepatobiliary indication, antioxidant and neuroprotective directions remain at the experimental or early clinical stage and <strong>do not constitute efficacy claims<\/strong>; finished-product labelling and claims must be assessed by the brand owner under the regulations of the target market.<\/div>\n        <div class=\"fact-list\">\n          <div class=\"fact\"><span class=\"n\">01<\/span><div><b>High purity, low impurities<\/b><span>Assay 98.0-102.0% (HPLC, anhydrous basis), with specified impurities such as taurine, UDCA and taurochenodeoxycholic acid controlled individually.<\/span><\/div><\/div>\n          <div class=\"fact\"><span class=\"n\">02<\/span><div><b>Fully traceable analytical methods<\/b><span>CP2020 methods plus GB 4789 microbiological methods; dual identification by IR and HPLC; COA issued per batch.<\/span><\/div><\/div>\n          <div class=\"fact\"><span class=\"n\">03<\/span><div><b>Powder properties suited to capsule filling<\/b><span>85% through 200 mesh; bulk density 0.25-0.4 g\/mL and tapped density 0.4-0.6 g\/mL for easy blending and automated production.<\/span><\/div><\/div>\n        <\/div>\n      <\/div>\n      <div>\n        <div class=\"mini-table\">\n          <h3>Physicochemical &amp; Developability Data <span style=\"font-weight:400;font-size:11px;color:var(--muted)\"><\/span><\/h3>\n          <table>\n            <tr><th>Formula<\/th><td class=\"mono\">C\u2082\u2086H\u2084\u2085NO\u2086S\uff08\u00b72H\u2082O\uff09<\/td><\/tr>\n            <tr><th>Molecular weight<\/th><td>499.71 (anhydrous) \/ 535.74 (dihydrate)<\/td><\/tr>\n            <tr><th>Appearance<\/th><td>White to off-white crystalline powder<\/td><\/tr>\n            <tr><th>Solubility<\/th><td>Freely soluble in methanol and ethanol; slightly soluble in water; insoluble in acetone<\/td><\/tr>\n            <tr><th>Specific rotation<\/th><td class=\"mono\">+41\u00b0 ~ +47\u00b0<\/td><\/tr>\n            <tr><th>pH (acidity)<\/th><td class=\"mono\">1.3 ~ 2.3<\/td><\/tr>\n            <tr><th>LogP \/ LogD<\/th><td class=\"mono\">2.20 \/ \u22120.17<\/td><\/tr>\n            <tr><th>TPSA \/ acidic pKa<\/th><td class=\"mono\">123.93 \/ 1.98<\/td><\/tr>\n            <tr><th>Solubility (predicted)<\/th><td class=\"mono\">26.55 mg\/mL<\/td><\/tr>\n            <tr><th>Plasma protein binding<\/th><td class=\"mono\">87.12% (human)<\/td><\/tr>\n          <\/table>\n          <div class=\"foot\">Sources: package insert, in-house specification sheet and the Global Drug Analysis System report (2026-01-16) AI developability predictions. Predicted values are for formulation and R&amp;D reference only.<\/div>\n        <\/div>\n        <div class=\"mini-table\" style=\"margin-top:20px\">\n          <h3>Nomenclature &amp; Registry<\/h3>\n          <table>\n            <tr><th>Chinese generic name<\/th><td>Tauroursodeoxycholic acid \/ taurine ursodeoxycholic acid<\/td><\/tr>\n            <tr><th>English name<\/th><td>Tauroursodeoxycholic Acid (TUDCA)<\/td><\/tr>\n            <tr><th>Common synonyms<\/th><td>TAUROLITE, Tudcabil, Taurolite\u00ae<\/td><\/tr>\n            <tr><th>ATC Code<\/th><td>A05AA02 Bile acids and derivatives<\/td><\/tr>\n            <tr><th>Dosage form (drug)<\/th><td>Hard capsule \/ oral, 250 mg<\/td><\/tr>\n          <\/table>\n        <\/div>\n      <\/div>\n    <\/div>\n  <\/div>\n<\/section>\n\n<!-- ============ \u8d28\u91cf\u89c4\u683c ============ -->\n<section id=\"spec\" class=\"tint\">\n  <div class=\"wrap\">\n    <div class=\"sec-head\">\n      <span class=\"en\">02 \/ Specification<\/span>\n      <span class=\"tag\">Specifications<\/span>\n      <h2>An in-house standard with item-by-item control<\/h2>\n      <p>The tables below are grouped by appearance, identification, assay and related substances, residual solvents, heavy metals, microbiology and powder properties. Standards follow the in-house specification sheet and COAs; typical results are drawn from three March 2025 batches and a publicly available peer COA.<\/p>\n    <\/div>\n    <div class=\"spec-grid\">\n      <div class=\"table-shell\">\n        <div class=\"table-top\"><h3>A. Appearance \u00b7 Identification \u00b7 Assay \u00b7 Related Substances<\/h3><p>Units: % or ppm<\/p><\/div>\n        <div class=\"table-scroll\">\n          <table class=\"data\">\n            <thead><tr><th style=\"width:28%\">Item<\/th><th style=\"width:30%\">Standard<\/th><th style=\"width:22%\">Typical Result<\/th><th style=\"width:20%\">Method<\/th><\/tr><\/thead>\n            <tbody>\n              <tr class=\"group\"><td colspan=\"4\">Appearance &amp; Identification<\/td><\/tr>\n              <tr><td>Appearance<\/td><td>White to off-white crystalline powder<\/td><td><span class=\"val\">Complies<\/span><\/td><td class=\"mono\">Visual<\/td><\/tr>\n              <tr><td>Solubility<\/td><td>Freely soluble in methanol\/ethanol; slightly soluble in water; insoluble in acetone<\/td><td><span class=\"val\">Complies<\/span><\/td><td class=\"mono\">CP2020<\/td><\/tr>\n              <tr><td>Identification A<\/td><td>IR spectrum conforms to reference standard<\/td><td><span class=\"val\">Conforms<\/span><\/td><td class=\"mono\">IR<\/td><\/tr>\n              <tr><td>Identification B<\/td><td>Principal peak retention time matches reference<\/td><td><span class=\"val\">Conforms<\/span><\/td><td class=\"mono\">HPLC<\/td><\/tr>\n              <tr class=\"group\"><td colspan=\"4\">Assay &amp; Related Substances<\/td><\/tr>\n              <tr><td>Assay (anhydrous basis)<\/td><td>98.0 ~ 102.0%\uff08\u226598%\uff09<\/td><td><span class=\"val\">99.6 ~ 99.8%<\/span><\/td><td class=\"mono\">HPLC<\/td><\/tr>\n              <tr><td>Water \/ Moisture<\/td><td>6.0-7.5% (spec sheet 6.5-7.5%)<\/td><td><span class=\"val\">6.9 ~ 7.0%<\/span><\/td><td class=\"mono\">CP2020-04-0832<\/td><\/tr>\n              <tr><td>Sulphated ash<\/td><td>\u2264 0.1%<\/td><td><span class=\"val\">0.05 ~ 0.06%<\/span><\/td><td class=\"mono\">CP2020-04-0841<\/td><\/tr>\n              <tr><td>Taurine<\/td><td>\u2264 0.15% (internal \u2264 0.1%)<\/td><td><span class=\"val\">&lt; 0.02%<\/span><\/td><td class=\"mono\">CP2020-04-0502<\/td><\/tr>\n              <tr><td>UDCA<\/td><td>\u2264 0.5% (spec sheet \u2264 0.4%)<\/td><td><span class=\"val\">0.05 ~ 0.10%<\/span><\/td><td class=\"mono\">CP2020-04-0502<\/td><\/tr>\n              <tr><td>TCDCA<\/td><td>\u2264 0.8% (internal \u2264 0.3%)<\/td><td><span class=\"val\">&lt; 0.01% \/ 0.30%<\/span><\/td><td class=\"mono\">HPLC<\/td><\/tr>\n              <tr><td>Other single impurity \/ total impurities<\/td><td>\u2264 0.4% \/ \u2264 0.5%<\/td><td><span class=\"val\">0.04% \/ 0.14%<\/span><\/td><td class=\"mono\">HPLC<\/td><\/tr>\n            <\/tbody>\n          <\/table>\n        <\/div>\n        <div class=\"table-note\"><b>Note:<\/b> In-house standards differ slightly between manufacturers for TCDCA and UDCA limits (0.3% \/ 0.8%, 0.4% \/ 0.5%). Both are listed here for benchmarking; the mutually agreed specification governs delivery.<\/div>\n      <\/div>\n\n      <div class=\"table-shell\">\n        <div class=\"table-top\"><h3>B. Residual Solvents \u00b7 Elemental Impurities \u00b7 Microbiology \u00b7 Powder<\/h3><p>Units: % \/ ppm \/ CFU\u00b7g\u207b\u00b9<\/p><\/div>\n        <div class=\"table-scroll\">\n          <table class=\"data\">\n            <thead><tr><th style=\"width:28%\">Item<\/th><th style=\"width:30%\">Standard<\/th><th style=\"width:22%\">Typical Result<\/th><th style=\"width:20%\">Method<\/th><\/tr><\/thead>\n            <tbody>\n              <tr class=\"group\"><td colspan=\"4\">Residual Solvents &amp; Inorganic Impurities<\/td><\/tr>\n              <tr><td>Triethylamine \/ ethanol<\/td><td>Each \u2264 0.5%<\/td><td><span class=\"val\">&lt;0.02% \/ 0.02%<\/span><\/td><td class=\"mono\">CP2020-04-0861<\/td><\/tr>\n              <tr><td>Isopropanol \/ acetone<\/td><td>Each \u2264 0.5%<\/td><td><span class=\"val\">&lt;0.01%<\/span><\/td><td class=\"mono\">CP2020-04-0861<\/td><\/tr>\n              <tr><td>Ethyl acetate (spec sheet)<\/td><td>\u2264 0.5%<\/td><td><span class=\"em\">Reported per batch<\/span><\/td><td class=\"mono\">GC<\/td><\/tr>\n              <tr><td>Chloride \/ sulphate<\/td><td>\u2264 0.02% \/ \u2264 0.05%<\/td><td><span class=\"em\">Reported per batch<\/span><\/td><td class=\"mono\">CP2020-04-0801<\/td><\/tr>\n              <tr><td>Arsenic salt<\/td><td>\u2264 0.0002%<\/td><td><span class=\"em\">Reported per batch<\/span><\/td><td class=\"mono\">CP2020-04-0822<\/td><\/tr>\n              <tr class=\"group\"><td colspan=\"4\">Heavy Metals &amp; Elemental Impurities<\/td><\/tr>\n              <tr><td>Total heavy metals<\/td><td>\u2264 10 ppm (common industry \u2264 20 ppm)<\/td><td><span class=\"val\">&lt; 10 ppm<\/span><\/td><td class=\"mono\">CP2020-04-0821<\/td><\/tr>\n              <tr><td>Pb \/ As \/ Cd<\/td><td>Each &lt; 1 ppm<\/td><td><span class=\"val\">Conforms<\/span><\/td><td class=\"mono\">CP2020-04-0821<\/td><\/tr>\n              <tr><td>Hg<\/td><td>&lt; 0.1 ppm (internal &lt; 1 ppm)<\/td><td><span class=\"val\">Conforms<\/span><\/td><td class=\"mono\">CP2020-04-0821<\/td><\/tr>\n              <tr class=\"group\"><td colspan=\"4\">Microbiological Limits<\/td><\/tr>\n              <tr><td>Total plate count<\/td><td>\u2264 1000 CFU\/g<\/td><td><span class=\"val\">Conforms<\/span><\/td><td class=\"mono\">GB 4789.2<\/td><\/tr>\n              <tr><td>Mould &amp; yeast<\/td><td>\u2264 100 CFU\/g<\/td><td><span class=\"val\">Conforms<\/span><\/td><td class=\"mono\">GB 4789.15<\/td><\/tr>\n              <tr><td>E. coli \/ Salmonella<\/td><td>Absent \/ 10 g<\/td><td><span class=\"val\">Not detected<\/span><\/td><td class=\"mono\">GB 4789.3\/.4<\/td><\/tr>\n              <tr><td>S. aureus<\/td><td>Absent \/ 10 g<\/td><td><span class=\"val\">Not detected<\/span><\/td><td class=\"mono\">GB 4789.10<\/td><\/tr>\n              <tr class=\"group\"><td colspan=\"4\">Powder Properties<\/td><\/tr>\n              <tr><td>Particle size<\/td><td>85% through 200 mesh<\/td><td><span class=\"em\">Customisable<\/span><\/td><td class=\"mono\">CP2020-01-0100<\/td><\/tr>\n              <tr><td>Bulk \/ tapped density<\/td><td>0.25~0.4 \/ 0.4~0.6 g\u00b7mL\u207b\u00b9<\/td><td><span class=\"em\">Customisable<\/span><\/td><td class=\"mono\">CP2020-04-0993<\/td><\/tr>\n            <\/tbody>\n          <\/table>\n        <\/div>\n        <div class=\"table-note\"><b>Note:<\/b> Method codes follow the in-house specification sheet (CP2020 internal methods) and GB 4789 national standards. The methods applied are those stated in the accompanying COA and the mutually agreed quality agreement.<\/div>\n      <\/div>\n    <\/div>\n  <\/div>\n<\/section>\n\n<!-- ============ \u6279\u6b21\u68c0\u9a8c\u6570\u636e ============ -->\n<section id=\"coa\">\n  <div class=\"wrap\">\n    <div class=\"sec-head\">\n      <span class=\"en\">03 \/ Batch COA Data<\/span>\n      <span class=\"tag\">Batch COA Data<\/span>\n      <h2>Three in-house batches + one industry benchmark<\/h2>\n      <p>Data below are taken directly from Certificates of Analysis. Batches 830-00250301 \/ 0303 and TUDCA-00250301 were manufactured in March 2025 with reports issued on 11 April 2025. The peer batch is included for public specification benchmarking and does not represent the product on this page.<\/p>\n    <\/div>\n    <div class=\"batch-grid\">\n      <div class=\"batch\">\n        <div class=\"batch-no mono\">BATCH 830-00250301<\/div>\n        <h4>Assay 99.8%<\/h4>\n        <dl>\n          <dt>Batch size<\/dt><dd class=\"mono\">60.2 kg<\/dd>\n          <dt>Mfg. date<\/dt><dd class=\"mono\">2025.03.20<\/dd>\n          <dt>Report date<\/dt><dd class=\"mono\">2025.04.11<\/dd>\n          <dt>Valid until<\/dt><dd class=\"mono\">2027.03.19<\/dd>\n          <dt>Water<\/dt><dd class=\"mono\">6.9%<\/dd>\n          <dt>Sulphated ash<\/dt><dd class=\"mono\">0.05%<\/dd>\n          <dt>Total impurities<\/dt><dd class=\"mono\">0.14%<\/dd>\n        <\/dl>\n        <div class=\"assay mono\">99.8% <small>HPLC assay (anhydrous)<\/small><\/div>\n      <\/div>\n      <div class=\"batch\">\n        <div class=\"batch-no mono\">BATCH 830-00250303<\/div>\n        <h4>Assay 99.7%<\/h4>\n        <dl>\n          <dt>Batch size<\/dt><dd class=\"mono\">60.4 kg<\/dd>\n          <dt>Mfg. date<\/dt><dd class=\"mono\">2025.03.28<\/dd>\n          <dt>Report date<\/dt><dd class=\"mono\">2025.04.11<\/dd>\n          <dt>Valid until<\/dt><dd class=\"mono\">2027.03.27<\/dd>\n          <dt>Water<\/dt><dd class=\"mono\">7.0%<\/dd>\n          <dt>Sulphated ash<\/dt><dd class=\"mono\">0.06%<\/dd>\n          <dt>Total impurities<\/dt><dd class=\"mono\">0.14%<\/dd>\n        <\/dl>\n        <div class=\"assay mono\">99.7% <small>HPLC assay (anhydrous)<\/small><\/div>\n      <\/div>\n      <div class=\"batch\">\n        <div class=\"batch-no mono\">TUDCA-00250301<\/div>\n        <h4>Assay 99.6%<\/h4>\n        <dl>\n          <dt>Packaging<\/dt><dd class=\"mono\">25 kg \/ drum<\/dd>\n          <dt>Mfg. date<\/dt><dd class=\"mono\">2025.03.20<\/dd>\n          <dt>Report No.<\/dt><dd class=\"mono\">TUDCAES002504001<\/dd>\n          <dt>Retest date<\/dt><dd class=\"mono\">2027.03.19<\/dd>\n          <dt>Water<\/dt><dd class=\"mono\">6.9%<\/dd>\n          <dt>Sulphated ash<\/dt><dd class=\"mono\">0.05%<\/dd>\n          <dt>UDCA impurity<\/dt><dd class=\"mono\">0.1%<\/dd>\n        <\/dl>\n        <div class=\"assay mono\">99.6% <small>English COA values<\/small><\/div>\n      <\/div>\n      <div class=\"batch peer\">\n        <div class=\"batch-no mono\">INDUSTRY REFERENCE \u00b7 20220810<\/div>\n        <h4>Industry benchmark 99.7%<\/h4>\n        <dl>\n          <dt>Batch size<\/dt><dd class=\"mono\">125 kg<\/dd>\n          <dt>Mfg. date<\/dt><dd class=\"mono\">2022.08.10<\/dd>\n          <dt>Test date<\/dt><dd class=\"mono\">2022.08.12<\/dd>\n          <dt>Valid until<\/dt><dd class=\"mono\">2024.08.09<\/dd>\n          <dt>Specific rotation<\/dt><dd class=\"mono\">+45.9\u00b0<\/dd>\n          <dt>Water<\/dt><dd class=\"mono\">7.2%<\/dd>\n          <dt>Sulphated ash<\/dt><dd class=\"mono\">0.04%<\/dd>\n        <\/dl>\n        <div class=\"assay mono\">99.7% <small>Public peer COA, benchmark only<\/small><\/div>\n      <\/div>\n    <\/div>\n\n    <div class=\"chart\">\n      <h3>Assay by Batch<\/h3>\n      <div class=\"sub\">Axis range 95-101%; the vertical line marks the 98.0% specification minimum. All batches are well above the limit.<\/div>\n      <div class=\"bar-row\"><span class=\"lbl mono\">830-00250301<\/span><div class=\"bar-track\"><span class=\"min\"><\/span><div class=\"bar-fill\" style=\"width:80%\"><\/div><\/div><span class=\"num mono\">99.8%<\/span><\/div>\n      <div class=\"bar-row\"><span class=\"lbl mono\">830-00250303<\/span><div class=\"bar-track\"><span class=\"min\"><\/span><div class=\"bar-fill\" style=\"width:78.3%\"><\/div><\/div><span class=\"num mono\">99.7%<\/span><\/div>\n      <div class=\"bar-row\"><span class=\"lbl mono\">TUDCA-00250301<\/span><div class=\"bar-track\"><span class=\"min\"><\/span><div class=\"bar-fill\" style=\"width:76.7%\"><\/div><\/div><span class=\"num mono\">99.6%<\/span><\/div>\n      <div class=\"bar-row\"><span class=\"lbl mono\">Industry benchmark batch<\/span><div class=\"bar-track\"><span class=\"min\"><\/span><div class=\"bar-fill\" style=\"width:78.3%;background:linear-gradient(90deg,#9DB5C1,#C9D8E0)\"><\/div><\/div><span class=\"num mono\">99.7%<\/span><\/div>\n      <div class=\"legend\">Sources: Zhejiang Hengkang Pharmaceutical CoA (Chinese \/ English versions) and a public peer COA; all assays by HPLC on the anhydrous basis.<\/div>\n    <\/div>\n  <\/div>\n<\/section>\n\n<!-- ============ \u5e94\u7528\u9886\u57df ============ -->\n<section id=\"application\" class=\"tint\">\n  <div class=\"wrap\">\n    <div class=\"sec-head\">\n      <span class=\"en\">04 \/ Applications<\/span>\n      <span class=\"tag\">Applications<\/span>\n      <h2>From hepatobiliary drugs to daily nutrition formulas<\/h2>\n      <p>Based on the package insert, supplement materials and the global R&amp;D report, downstream uses of TUDCA fall into three areas. The descriptions below summarise literature and source materials and do not imply that this ingredient has been approved for the corresponding indications.<\/p>\n    <\/div>\n    <div class=\"app-grid\">\n      <article class=\"app\">\n        <div class=\"ico\"><svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"#9A6E14\" stroke-width=\"1.7\" stroke-linecap=\"round\"><path d=\"M12 3.5c3.2 0 5.5 2.4 5.5 5.3 0 3.6-5.5 8.2-5.5 8.2S6.5 12.4 6.5 8.8C6.5 5.9 8.8 3.5 12 3.5Z\"\/><path d=\"M4 14.5c1.5 2 3.4 3.2 5.6 3.6M20 14.5c-1.5 2-3.4 3.2-5.6 3.6M12 17v4\"\/><\/svg><\/div>\n        <span class=\"kicker\">Dietary Supplements<\/span>\n        <h3>Dietary Supplement Ingredient<\/h3>\n        <p>Capsule and tablet formulas supporting liver health, normal bile flow and cellular stress relief. Overseas finished products are mainly 250 mg \/ 500 mg capsules, commonly combined with creatine, vitamin K2 (MK-7), vitamin D3, D-biotin, berberine and L-glutathione.<\/p>\n        <ul>\n          <li>Typical formula intake: 500-1500 mg \/ day in divided doses<\/li>\n          <li>Common formats: 250 mg \u00d7 60 capsules, 500 mg \u00d7 30 capsules<\/li>\n          <li>Generally well tolerated; occasional mild GI effects such as diarrhoea or bloating<\/li>\n        <\/ul>\n        <p class=\"disclaim\">Supplement regulations differ from those for drugs. Dosage, contraindicated populations and label claims must be assessed by the brand owner under target-market regulations, and used under medical supervision.<\/p>\n      <\/article>\n      <article class=\"app\">\n        <div class=\"ico\"><svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"#9A6E14\" stroke-width=\"1.7\" stroke-linecap=\"round\"><rect x=\"4\" y=\"8\" width=\"16\" height=\"10\" rx=\"5\"\/><path d=\"M4 13h16M12 8v10M8 3.5h8M12 3.5V6\"\/><\/svg><\/div>\n        <span class=\"kicker\">Pharmaceutical \/ API<\/span>\n        <h3>Pharmaceutical Formulations &amp; API<\/h3>\n        <p>Tauroursodeoxycholic acid capsules (TAUROLITE\u00ae) are a marketed drug at 250 mg, indicated for dissolving radiolucent cholesterol gallstones smaller than 2 cm. The package insert states a usual dose of 5-10 mg\/kg\/day in 2-3 divided doses after meals.<\/p>\n        <ul>\n          <li>Approval No. H20110233 | Standard JX20140229<\/li>\n          <li>Pack: blister, 20 capsules\/box | Shelf life 36 months<\/li>\n          <li>Originator: Bruschettini S.r.l. (Genoa, Italy)<\/li>\n          <li>Absorbed in the small intestine; high hepatic first-pass effect; enterohepatic circulation<\/li>\n        <\/ul>\n        <p class=\"disclaim\">The above is public package-insert information shown only to illustrate downstream use. Suitability of this ingredient for registration or filings must be assessed by the customer.<\/p>\n      <\/article>\n      <article class=\"app\">\n        <div class=\"ico\"><svg viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"#9A6E14\" stroke-width=\"1.7\" stroke-linecap=\"round\"><path d=\"M9 3.5h6M10 3.5v5.2L5.6 16a2.6 2.6 0 0 0 2.2 4h8.4a2.6 2.6 0 0 0 2.2-4L14 8.7V3.5\"\/><path d=\"M7.2 15h9.6M9 18.5h6\"\/><\/svg><\/div>\n        <span class=\"kicker\">Research &amp; Pipeline<\/span>\n        <h3>Research &amp; Drug Discovery<\/h3>\n        <p>A GPBAR1 (TGR5) agonist that acts as a chemical chaperone to reduce endoplasmic reticulum stress. Beyond the approved liver and gallstone indications, the ALS direction has reached Phase III in several EU countries; metabolic and neurodegenerative directions have extensive preclinical literature.<\/p>\n        <ul>\n          <li>ALS Phase III: EUCTR2018-002722-22 (NL \/ GB \/ DE, etc.)<\/li>\n          <li>Science (2006, Harvard): ER stress in a type 2 diabetes mouse model<\/li>\n          <li>63 global patents, 10 pipeline drugs, 11 companies<\/li>\n        <\/ul>\n        <p class=\"disclaim\">Investigational indications are not approved; these statements are excerpts of public R&amp;D progress and do not constitute efficacy or indication claims.<\/p>\n      <\/article>\n    <\/div>\n  <\/div>\n<\/section>\n\n<!-- ============ \u6cd5\u89c4\u4e0e\u7814\u53d1 ============ -->\n<section id=\"regulatory\">\n  <div class=\"wrap\">\n    <div class=\"sec-head\">\n      <span class=\"en\">05 \/ Regulatory &amp; Development<\/span>\n      <span class=\"tag\">Regulatory &#038; R&#038;D Progress<\/span>\n      <h2>A molecule with two decades on the market<\/h2>\n      <p>Timeline compiled from the Global Drug Analysis System drug report (2026-01-16), covering registration filings, marketing approvals and ongoing clinical trials.<\/p>\n    <\/div>\n    <div class=\"timeline\">\n      <div class=\"tl\"><div class=\"date mono\">2000.01.01<\/div><h4>First China registration filing<\/h4><p>Acceptance No. A19990115, hard capsule for oral use; originator Bruschettini S.r.l. (Italy), with Quanfu Development Co., Ltd. as another applicant.<\/p><\/div>\n      <div class=\"tl\"><div class=\"date mono\">2006.07.25<\/div><h4>First approval in China \/ worldwide<\/h4><p>Approval No. HJ20150398, indication: cholelithiasis, 250 mg; liver-related indications also approved in Italy and the EU in the same period.<\/p><\/div>\n      <div class=\"tl\"><div class=\"date mono\">2008.08.22<\/div><h4>First China clinical trial application<\/h4><p>Acceptance No. JXHL0800270, hard capsule for oral use; an additional registration filing JXHS1300103 was recorded in 2013.<\/p><\/div>\n      <div class=\"tl\"><div class=\"date mono\">From Jan 2019<\/div><h4>ALS indication enters Phase III<\/h4><p>The EUCTR2018-002722-22 trial series advanced across the EU, France, Italy, Germany, Belgium, the UK, Ireland and the Netherlands.<\/p><\/div>\n      <div class=\"tl\"><div class=\"date mono\">2025.10.27<\/div><h4>China approval information updated<\/h4><p>Latest update recorded in the drug report; the highest global development stage remains &#8216;Marketed&#8217;.<\/p><\/div>\n      <div class=\"tl\"><div class=\"date mono\">2026.01.16<\/div><h4>Global R&amp;D Snapshot<\/h4><p>Report statistics: 63 patents, 3 indications (2 approved \/ 1 in development), 8 clinical records, 1 translational medicine record; ranked 1\/11 in the field.<\/p><\/div>\n    <\/div>\n    <div class=\"reg-grid\">\n      <div class=\"reg\"><b class=\"mono\">A05AA02<\/b><span>ATC: Bile acids and derivatives<\/span><\/div>\n      <div class=\"reg\"><b class=\"mono\">GPBAR1<\/b><span>Target: GPBAR1 agonist<\/span><\/div>\n      <div class=\"reg\"><b class=\"mono\">63<\/b><span>Global published patents<\/span><\/div>\n      <div class=\"reg\"><b class=\"mono\">Phase III<\/b><span>Highest global ALS development stage<\/span><\/div>\n    <\/div>\n  <\/div>\n<\/section>\n\n<!-- ============ \u5e02\u573a\u4e0e\u5de5\u827a ============ -->\n<section id=\"market\" class=\"tint\">\n  <div class=\"wrap\">\n    <div class=\"sec-head\">\n      <span class=\"en\">06 \/ Market &amp; Process<\/span>\n      <span class=\"tag\">Market Insights &#038; Synthetic Route<\/span>\n      <h2>Where demand comes from, how the molecule is made<\/h2>\n      <p>The market section is based on global import customs records containing &#8216;TUDCA&#8217; from 2024-01-01 to 2026-01-16; the process section is based on published synthetic routes and upstream UDCA test data.<\/p>\n    <\/div>\n    <div class=\"market-grid\">\n      <div class=\"panel\">\n        <h3>Global Trade &amp; Product Forms<\/h3>\n        <p>Customs records show that TUDCA-containing shipments are primarily <strong>exported from China and imported overseas<\/strong>, with the United States as the main destination, followed by Ecuador, Russia, Uzbekistan and India. Descriptions include both ingredient-grade names and a large number of finished capsule products, indicating a mature supplement supply chain.<\/p>\n        <div class=\"tags\">\n          <span>USA \u00b7 Main destination<\/span><span>NUTRICOST 250 mg \/ 500 mg capsules<\/span><span>Creatine blends<\/span><span>Vitamin K2 (MK-7)<\/span><span>Vitamin D3<\/span><span>D-Biotin<\/span><span>Berberine HCl<\/span><span>Alpha-lipoic acid<\/span><span>L-Glutathione<\/span><span>Fibre drums \/ blended formulas<\/span>\n        <\/div>\n        <div class=\"market-stats\">\n          <div><b class=\"mono\">70+<\/b><span>import records (sample)<\/span><\/div>\n          <div><b class=\"mono\">2024.01\u20132026.01<\/b><span>Data period<\/span><\/div>\n          <div><b class=\"mono\">250 \/ 500 mg<\/b><span>Mainstream finished capsule strengths<\/span><\/div>\n        <\/div>\n        <p style=\"font-size:11.5px;color:var(--muted);margin-top:14px\">Note: customs records cover mixed goods and finished products &#8216;containing TUDCA&#8217; and do not equal export tonnage of TUDCA ingredient; they are used only to infer product forms and regional flows.<\/p>\n      <\/div>\n      <div class=\"panel\">\n        <h3>Synthetic Route &amp; Upstream Raw Material<\/h3>\n        <p>The mainstream route condenses ursodeoxycholic acid (UDCA, CAS 128-13-2) with taurine (CAS 107-35-7); published literature also describes microbial hydroxylation routes.<\/p>\n        <div class=\"route\">\n          <div class=\"route-step\"><b>1<\/b><div><strong>Carboxyl activation<\/strong><span>Ethyl chloroformate \/ triethylamine forms a mixed anhydride; pivaloyl chloride or benzoyl chloride activation and active phenyl esters are also used.<\/span><\/div><\/div>\n          <div class=\"route-arrow\">\u2193<\/div>\n          <div class=\"route-step\"><b>2<\/b><div><strong>Coupling with taurine<\/strong><span>Condensation with taurine triethylamine salt; direct coupling with IIDQ, DEPC or EEDQ under microwave conditions is also reported.<\/span><\/div><\/div>\n          <div class=\"route-arrow\">\u2193<\/div>\n          <div class=\"route-step\"><b>3<\/b><div><strong>Purification &amp; crystallisation<\/strong><span>TUDCA dihydrate is obtained, then packaged after control of water, related substances and residual solvents.<\/span><\/div><\/div>\n        <\/div>\n        <div style=\"margin-top:18px;padding:14px 16px;background:#FBFDFF;border:1px solid var(--line2);border-radius:10px\">\n          <strong style=\"display:block;font-size:13.5px;color:var(--navy);margin-bottom:8px\">Upstream UDCA test data (EP 11.0)<\/strong>\n          <p style=\"font-size:12.5px;line-height:1.85\">Batch 20250308 \/ 600 kg: assay  <b>100.1%<\/b> (spec 99.0-101.0%), specific rotation  <b>+60.3\u00b0<\/b> (+58\u00b0 to +62\u00b0), melting point  <b>203.1 \u2103<\/b> (200-204 \u00b0C), loss on drying 0.40%, sulphated ash 0.06%, impurity A 0.39%, total impurities 0.60%; complies with EP 11.0.<\/p>\n        <\/div>\n      <\/div>\n    <\/div>\n  <\/div>\n<\/section>\n\n<!-- ============ \u5305\u88c5\u4e0e\u4ea4\u4ed8 ============ -->\n<section id=\"delivery\">\n  <div class=\"wrap\">\n    <div class=\"sec-head\">\n      <span class=\"en\">07 \/ Packaging &amp; Supply<\/span>\n      <span class=\"tag\">Packaging, Storage &amp; Documents<\/span>\n      <h2>Traceable, batch-wise delivery<\/h2>\n      <p>Compiled from packaging, storage and retest information in COAs and the package insert; the mutually agreed order and quality agreement govern.<\/p>\n    <\/div>\n    <div class=\"pack-grid\">\n      <div class=\"pack-card\">\n        <h3>Packaging &amp; Storage<\/h3>\n        <dl class=\"kv\">\n          <dt>Standard pack<\/dt><dd>25 kg \/ fibre drum with moisture-barrier liner<\/dd>\n          <dt>Example batch sizes<\/dt><dd>600 kg (March 2025 batches)<\/dd>\n          <dt>Storage<\/dt><dd>Protect from light; keep tightly closed and dry at \u2264 30 \u00b0C<\/dd>\n          <dt>Retest period<\/dt><dd>24 months (example batches to Mar 2027)<\/dd>\n          <dt>Upstream reference<\/dt><dd>UDCA 600 kg \/ batch, complies with EP 11.0<\/dd>\n          <dt>Handling<\/dt><dd>Keep dry, avoid heavy stacking and co-loading with odorous goods<\/dd>\n        <\/dl>\n      <\/div>\n      <div class=\"pack-card\">\n        <h3>Technical documents available<\/h3>\n        <div class=\"doc-list\">\n          <div class=\"doc\"><span class=\"fico\">COA<\/span><span class=\"fname\"><b>Certificates of Analysis (Chinese \/ English)<\/b><span>Batches 830-00250301, 830-00250303, TUDCA-00250301<\/span><\/span><span class=\"fstat\">Available<\/span><\/div>\n          <div class=\"doc\"><span class=\"fico\">SPEC<\/span><span class=\"fname\"><b>In-house specification sheet (with method codes)<\/b><span>CP2020 \/ GB 4789 series \/ HPLC<\/span><\/span><span class=\"fstat\">Available<\/span><\/div>\n          <div class=\"doc\"><span class=\"fico\">PDF<\/span><span class=\"fname\"><b>Package insert &amp; <\/b><\/span><span class=\"fstat\">Reference<\/span><\/div>\n          <div class=\"doc\"><span class=\"fico\">MSDS<\/span><span class=\"fname\"><b>SDS \/ transport classification \/ quality agreement<\/b><span>Supplied to customer compliance requirements<\/span><\/span><span class=\"fstat\">On request<\/span><\/div>\n          \n        <\/div>\n      <\/div>\n    <\/div>\n  <\/div>\n<\/section>\n\n<!-- ============ FAQ ============ -->\n<section id=\"faq\" class=\"tint\">\n  <div class=\"wrap\">\n    <div class=\"sec-head\">\n      <span class=\"en\">08 \/ FAQ<\/span>\n      <span class=\"tag\">FAQ<\/span>\n      <h2>Common questions before sourcing<\/h2>\n    <\/div>\n    <div class=\"faq\">\n      <details open><summary>What is the difference between TUDCA and UDCA?<\/summary><div class=\"ans\">TUDCA is the conjugate of UDCA with taurine; the taurine group (with a sulfonic acid moiety) makes it more hydrophilic. It is produced by condensing UDCA (CAS 128-13-2) with taurine (CAS 107-35-7), so UDCA is both the upstream raw material and a specified impurity controlled in the COA (limit \u2264 0.5%; measured 0.05-0.10%).<\/div><\/details>\n      <details><summary>Is 6-7.5% water content high? Does it affect the assay?<\/summary><div class=\"ans\">No &#8211; it is not incomplete drying. TUDCA commonly occurs as a dihydrate (formula C\u2082\u2086H\u2084\u2085NO\u2086S\u00b72H\u2082O, MW 535.74); the theoretical water content of the crystal water is about 6.7%, consistent with the 6.0-7.5% specification. The in-house assay is expressed on the <strong>anhydrous basis<\/strong> (98.0-102.0%), so water and assay must be read together.<\/div><\/details>\n      <details><summary>Why are both \u226598% and 98.0-102.0% used for the assay?<\/summary><div class=\"ans\">They come from different versions of the in-house specification sheet and COA: the spec sheet usually states &#8216;\u226598%&#8217;, while the CoA follows pharmacopoeial convention with &#8216;98.0-102.0%&#8217; (anhydrous basis). Measured batches on this page fall in 99.6-99.8% and satisfy both conventions. The mutually agreed specification governs delivery.<\/div><\/details>\n      <details><summary>Can you provide samples, custom particle size or small trial batches?<\/summary><div class=\"ans\">Yes. Standard pack is 25 kg\/drum, with 85% through 200 mesh, bulk density 0.25-0.4 g\/mL and tapped density 0.4-0.6 g\/mL. For a specific particle size distribution, bulk density or alternative pack size, please state the target dosage form (capsule \/ tablet \/ powder) and filling method in your enquiry and we will evaluate it.<\/div><\/details>\n      <details><summary>Can this ingredient be used directly in supplement or drug filings?<\/summary><div class=\"ans\">This is a B2B ingredient information page. The regulatory and R&amp;D progress shown here is compiled from public sources and <strong>does not mean this ingredient has obtained any registration, filing or indication approval<\/strong>. Market access requirements for bile acid ingredients vary considerably; the filing pathway and required dossiers (e.g. DMF\/CTD, stability, toxicology) must be assessed by the customer under target-market regulations. We can supply supporting technical documents.<\/div><\/details>\n      <details><summary>Can the efficacy descriptions on this page be printed on product labels?<\/summary><div class=\"ans\">We do not recommend quoting them directly. Apart from the approved hepatobiliary indication, antioxidant, cytoprotective and neuroprotective directions derive mostly from experimental or early clinical research and are descriptions of scientific progress. Finished-product labels and claims must be independently assessed by the brand owner under the regulations of the market of sale (including China health-food \/ novel food ingredient rules, US DSHEA and EU Novel Food).<\/div><\/details>\n    <\/div>\n  <\/div>\n<\/section>\n\n<!-- ============ CTA ============ -->\n<section class=\"cta\" id=\"contact\">\n  <div class=\"wrap\">\n    <div>\n      <h2>Need a TUDCA sample, specification sheet or batch COA?<\/h2>\n      <p>Our technical and commercial teams can support formulation, regulatory documentation advice and custom specification assessment. Urgent enquiries are answered within 4 working hours.<\/p>\n    <\/div>\n    <div class=\"cta-btns\">\n      <a class=\"btn btn-gold\" href=\"mailto:bd1@nugene.com.cn?subject=TUDCA%20%E6%A0%B7%E5%93%81%E4%B8%8E%20COA%20%E5%92%A8%E8%AF%A2\">\u2709 Send an Enquiry<\/a>\n      <a class=\"btn btn-outline\" href=\"tel:008613326014885\">\u260f (0086) 133-26014885<\/a>\n    <\/div>\n  <\/div>\n<\/section>\n\n<!-- ============ \u9875\u811a\uff08\u5f15\u7528\u5b98\u7f51\u4fe1\u606f\uff09 ============ -->\n<!-- ==== \u3010\u53ef\u5220\u9664\u00b7\u82e5\u4e3b\u9898\u5df2\u6709\u5168\u7ad9\u9875\u811a\u3011\u7ad9\u70b9\u9875\u811a \u5f00\u59cb ==== -->\n<footer class=\"site-footer\">\n  <div class=\"wrap\">\n    <div class=\"foot-grid\">\n      <div>\n        <div class=\"foot-brand\"><span class=\"brand-mark\" aria-hidden=\"true\"><\/span><div><strong>NuGene Pharma (Shandong) Co., Ltd.<\/strong><span>NUGENE PHARMA (SHANDONG) CO., LTD.<\/span><\/div><\/div>\n        <p class=\"about\">Advanced biosynthesis solutions for limitless possibilities. A leading producer of PQQ and SAMe, focused on fermentation technology, nutraceutical ingredients, enzymes and synthetic biology, serving pharmaceutical and nutrition customers worldwide.<\/p>\n        <span class=\"fbadge\">FDA Registration No.: 16709784862<\/span>\n      <\/div>\n      <div>\n        <h4>Products<\/h4>\n        <ul>\n          <li><a href=\"https:\/\/shandong.nugene.com.cn\/index.php\/%e5%90%a1%e5%92%af%e5%96%b9%e5%95%89%e9%86%8c%e4%ba%8c%e9%92%a0%e7%9b%90pqq\/\">VigouFull\u00ae PQQ<\/a><\/li>\n          <li><a href=\"https:\/\/shandong.nugene.com.cn\/index.php\/%e8%85%ba%e8%8b%b7%e8%9b%8b%e6%b0%a8%e9%85%b8%e5%af%b9%e7%94%b2%e8%8b%af%e7%a3%ba%e9%85%b8%e7%a1%ab%e9%85%b8%e7%9b%90same\/\">SAMe (S-Adenosyl-L-Methionine)<\/a><\/li>\n          <li><a href=\"https:\/\/en.hengkangpharm.cn\/index.php\/apis\/\">NMN \/ APIs<\/a><\/li>\n          <li><a href=\"https:\/\/shandong.nugene.com.cn\/index.php\/TUDCA.html\">TUDCA (Tauroursodeoxycholic Acid)<\/a><\/li>\n        <\/ul>\n      <\/div>\n      <div>\n        <h4>Quick Links<\/h4>\n        <ul>\n          <li><a href=\"https:\/\/shandong.nugene.com.cn\/\">Home<\/a><\/li>\n          <li><a href=\"https:\/\/shandong.nugene.com.cn\/index.php\/%e5%85%b3%e4%ba%8e%e6%88%91%e4%bb%ac\/\">About Us<\/a><\/li>\n          <li><a href=\"https:\/\/shandong.nugene.com.cn\/#quality\">Quality &#038; Certifications<\/a><\/li>\n          <li><a href=\"https:\/\/shandong.nugene.com.cn\/#cmo\">CMO \/ CDMO Services<\/a><\/li>\n          <li><a href=\"https:\/\/shandong.nugene.com.cn\/index.php\/%e8%81%94%e7%b3%bb%e6%88%91%e4%bb%ac\/\">Contact Us<\/a><\/li>\n        <\/ul>\n      <\/div>\n      <div>\n        <h4>Contact Us<\/h4>\n        <ul>\n          <li>\u26df No. 8 Dongwaihuan Road, High-Tech Zone, Jining, Shandong, P.R. China<\/li>\n          <li>\u260f <a href=\"tel:057156908575\">(0571) 569-08575<\/a><\/li>\n          <li>\u2121 <a href=\"tel:008613326014885\">(0086) 133-26014885<\/a><\/li>\n          <li>\u2709 <a href=\"mailto:bd1@nugene.com.cn\">bd1@nugene.com.cn<\/a><\/li>\n          <li>\ud83d\udcac WeChat: 13326014885<\/li>\n          <li>\ud83d\udd17 <a href=\"https:\/\/www.linkedin.com\/company\/nugene-pharma-shandong-co-ltd\/\">LinkedIn\uff1aNuGene Pharma (Shandong)<\/a><\/li>\n        <\/ul>\n      <\/div>\n    <\/div>\n    <div class=\"foot-bottom\">\n      <span>\u00a9 <span id=\"year\">2026<\/span> NuGene Pharma (Shandong) Co., Ltd. All rights reserved.<\/span>\n      <span>Content on this page is compiled from the public package insert, COAs, in-house specifications, industry reports and customs data. For B2B technical and commercial reference only; not medical advice or a guarantee of efficacy.<a href=\"#overview\">Back to top<\/a><a href=\"https:\/\/shandong.nugene.com.cn\/index.php\/TUDCA.html\" hreflang=\"zh-CN\">Chinese Site<\/a><\/span>\n    <\/div>\n  <\/div>\n<\/footer>\n\n<button id=\"topBtn\" aria-label=\"Back to top\">\u2191<\/button>\n<\/div>\n<script>\n(function(){\n  var root=document.getElementById('tudca-page'); if(!root) return;\n  \/* \u7528\u771f\u5b9e\u89c6\u53e3\u5bbd\u5ea6\uff08\u4e0d\u542b\u6eda\u52a8\u6761\uff09\u9a71\u52a8\u5168\u5bbd\u7834\u5bb9\u5668\uff0c\u907f\u514d\u6a2a\u5411\u6eda\u52a8 *\/\n  function setVw(){root.style.setProperty('--vw',(document.documentElement.clientWidth||window.innerWidth)+'px');}\n  setVw();\n  window.addEventListener('resize',setVw,{passive:true});\n  window.addEventListener('orientationchange',setVw);\n  \/* \u70b9\u51fb\u5bfc\u822a\u540e\u6536\u8d77\u79fb\u52a8\u7aef\u83dc\u5355\uff08\u811a\u672c\u88ab\u8fc7\u6ee4\u65f6\u83dc\u5355\u4ecd\u53ef\u7528\uff0c\u53ea\u662f\u4e0d\u81ea\u52a8\u6536\u8d77\uff09 *\/\n  var chk=document.getElementById('tudcaNav');\n  if(chk) Array.prototype.forEach.call(root.querySelectorAll('.main-nav a'),function(a){\n    a.addEventListener('click',function(){chk.checked=false;});\n  });\n  var links=Array.prototype.slice.call(root.querySelectorAll('#subNav a'));\n  var targets=links.map(function(a){return document.querySelector(a.getAttribute('href'));}).filter(Boolean);\n  var topBtn=document.getElementById('topBtn');\n  function onScroll(){\n    var y=window.scrollY+160,idx=0;\n    targets.forEach(function(t,i){if(t.getBoundingClientRect().top+window.scrollY<=y)idx=i;});\n    links.forEach(function(a,i){a.classList.toggle('on',i===idx);});\n    if(topBtn) topBtn.classList.toggle('show',window.scrollY>500);\n  }\n  window.addEventListener('scroll',onScroll,{passive:true}); onScroll();\n  if(topBtn) topBtn.addEventListener('click',function(){window.scrollTo({top:0,behavior:'smooth'});});\n  var yr=document.getElementById('year'); if(yr) yr.textContent=new Date().getFullYear();\n})();\n<\/script>\n","protected":false},"excerpt":{"rendered":"<p>Overview Specifications Batch COA Data Applications Regulatory &#038; R&#038;D Market &#038; Process Packaging &#038; Delivery FAQ Home \/ Products \/ Nutraceutical &amp; Pharma Ingredients \/ Tauroursodeoxycholic Acid (TUDCA) Nutraceutical &amp; Pharmaceutical Ingredient Tauroursodeoxycholic AcidTUDCA \u00b7 CAS 14605-22-2 \u00b7 High-Purity Bile Acid Ingredient A hydrophilic bile acid formed by conjugating ursodeoxycholic acid (UDCA) with taurine. 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